What is lymphocyte morphology?
The morphology of lymphocytes is complex; cell size, amount and colour of cytoplasm, as well as shape and chromatin structure of the nucleus, must be combined to come to a good characterisation of the lymphocyte. Diagnosis of infectious mononucleosis may be based on Hoagland’s criteria.
What does it mean when your lymphocytes are abnormal?
High lymphocyte blood levels indicate your body is dealing with an infection or other inflammatory condition. Most often, a temporarily high lymphocyte count is a normal effect of your body’s immune system working. Sometimes, lymphocyte levels are elevated because of a serious condition, like leukemia.
What is lymphocyte disorder?
Lymphocytopenia is an abnormally low number of lymphocytes (a type of white blood cell) in the blood. Many disorders can decrease the number of lymphocytes in the blood, but viral infections (including AIDS) and undernutrition are the most common.
What can cause atypical lymphocytes?
A large number of atypical lymphocytes are often found in viral infections like mononucleosis, cytomegalovirus infections and hepatitis B. Toxoplasmosis, certain bacterial infections, medications, stress and autoimmune diseases can also be accompanied by a larger number of atypical lymphocytes.
Which is an example of a non neoplastic morphologic disorder?
Exemplary non‐neoplastic disorders with distinctive morphologic blood features of RBC, neutrophils, monocytes, and lymphocytes will be highlighted. The differential diagnostic considerations in blood smears with RBC destruction will be presented, expanding beyond microangiopathic hemolytic anemia.
What are non-neoplastic abnormalities of white blood cells?
Acquired Abnormalities of White Blood Cells 1 “Toxic” Changes in Leukocytes. Increased WBC counts (e.g., leukocytosis) can be seen in a wide variety of conditions. 2 Cytokine Effects. Cytokine therapy has become commonplace. 3 Megaloblastic and Dysplastic Changes. 4 Eosinophils. 5 Reactive Lymphocytes and Lymphocytosis.
Is there a standard definition of abnormal lymphocytes?
The ability of individual technicians, however, to recognise abnormal lymphocytes is consistently quite poor. 5 There are no standardised definitions regarding the morphology of the various cells, and interpretation is based on individual experience and dependent on the availability of additional clinical information.
How to differentiate between reactive and neoplastic lymphocytes?
With small/mature lymphocytes, morphology alone is not sufficient to identify reactive versus neoplastic proliferations, though certain magnitudes can increase suspicion of neoplasia. Thus additional steps must be taken to separate the two processes. These steps can include flow cytometry, establishing clonality (to be