What does 5ht2a receptor do?
The 5-HT2A receptor is a cell surface receptor. 5-HT is short for 5-hydroxy-tryptamine, which is serotonin. This is the main excitatory receptor subtype among the GPCRs for serotonin, although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex.
Where are 5ht2a receptors located?
It was defined as the classical D receptor initially by Gaddum and Picarelli (1957), and later referred as the 5-HT2 receptor by Peroutka and Snyder (1979). The 5-HT2AR gene is located on human chromosome 13q14-q21. HTR2A gene codes for a 471-amino acid sequence in rat, mouse, and human (Sparkes et al., 1991).
What is serotonin type 2A?
The serotonin 2A receptor (5-HT2A) has been implicated in mental disorders with complex etiologies that are still not clearly understood, in processes such as learning and memory, and also in neurogenesis. There are a large number of drugs targeted to this receptor.
Are SSRIs agonists or antagonists?
Fluoxetine and all other SSRIs are 5-HT2B Agonists – Importance for their Therapeutic Effects.
Are there any drugs that work on the 5 HT2A receptor?
Silent antagonists Trazodone is a potent 5-HT2A antagonist, as well as an antagonist on other serotonin receptors. Mirtazapine is a 5-HT2A, 5-HT2C, and 5-HT3 antagonist. Mirtazapine also has an antagonistic effect on H1 histamine receptors.
Are there any antidepressants that Block 5 HT2A?
This review summarizes information about the association between the 5-HT2A receptor gene and its relevance to schizophrenia, tardive dyskinesia, major depression, suicidality, anorexia nervosa and obsessive-compulsive disorder. Evidence is presented that implies that selective 5-HT2A antagonists may be considered useful in investigating…
Are there any psychiatric disorders associated with 5 HT2A?
This review summarizes information about the association between the 5-HT2A receptor gene and its relevance to schizophrenia, tardive dyskinesia, major depression, suicidality, anorexia nervosa and obsessive-compulsive disorder.
How are selective 5 HT2A antagonists used in the treatment of psychosis?
Evidence is presented that implies that selective 5-HT2A antagonists may be considered useful in investigating the role of 5-HT2A receptor function and in the treatment of psychosis, and possibly alcohol and cocaine dependence.