What does septin do?

What does septin do?

Assembled as such, septins function in cells by localizing other proteins, either by providing a scaffold to which proteins can attach, or by forming a barrier preventing the diffusion of molecules from one compartment of the cell to another, or in the cell cortex as a barrier to the diffusion of membrane-bound …

When were septins discovered?

Septins were first discovered in S. cerevisiae (Hartwell, 1971; Longtine et al., 1996). They constitute a conserved family of GTP-binding proteins found in eukaryotes from yeasts to mammals.

Are Septins intermediate filaments?

Septins are able to polymerize into long apolar filaments and have long been considered to be a component of the cytoskeleton alongside intermediate filaments (which are also apolar in nature), microtubules and actin filaments (which are not).

What are the side effects of septrin tablets?

Side effects

  • fever.
  • feeling generally unwell or extremely tired.
  • muscle or joint ache.
  • blistering of the skin.
  • mouth ulcers.
  • swelling of the eyes, lips, mouth or face.
  • breathing difficulties.
  • yellowing of the skin or eyes.

How are protein complexes formed in a septin?

Different septins form protein complexes with each other. These complexes can further assemble into filaments, rings and gauzes.

What are septins and how are they used in cells?

Since the discovery of septins in yeast, proteins with homologous sequences have been identified in nearly all eukaryotes, including humans 5, 6, 7. All septins are GTP-binding proteins that control cellular processes by polymerizing into hetero-oligomeric protein complexes that can further form filaments.

How does the composition of the septin cortex vary?

The composition of the septin cortex does not only vary throughout the cell cycle but also along the mother-bud axis. This polarity of the septin network allows concentration of some proteins primarily to the mother side of the neck, some to the center and others to the bud site. The septins act as a scaffold, recruiting many proteins.

Where are septins found in the human body?

Septins are enriched in the mid-cell zone and at the cell cortex and expand also into the uropod. The role of septins in T-cell morphology and migration has been studied by shRNA-mediated downregulation of septin 7, which also suppresses expression of the other isoforms.