How does terbutaline work in pregnancy?

How does terbutaline work in pregnancy?

Terbutaline is in a class of drugs called betamimetics. They help prevent and slow contractions of the uterus. It may help delay birth for several hours or days. During that period, doctors can administer other drugs to help ensure the baby is born as healthy as possible.

How does terbutaline cause tachycardia?

The marked hypokalaemia induced by terbutaline most likely contributes to the tachycardia and decreased variability cardiovascular indices by increasing the slope and amplitude of action potential in sinoatrial and atrioventricular nodes.

What is Tocolysis in pregnancy?

Tocolytics are drugs that are used to delay your delivery for a short time (up to 48 hours) if you begin labor too early in your pregnancy.

Why is terbutaline contraindicated in pregnancy?

[02-17-2011] The U.S. Food and Drug Administration (FDA) is warning the public that injectable terbutaline should not be used in pregnant women for prevention or prolonged treatment (beyond 48-72 hours) of preterm labor in either the hospital or outpatient setting because of the potential for serious maternal heart …

How is terbutaline used to treat preterm labor?

The drug is sometimes used off-label (an unapproved use) for acute obstetric uses, including treating preterm labor and treating uterine hyperstimulation. Terbutaline has also been used off-label over longer periods of time in an attempt to prevent recurrent preterm labor.

Are there any side effects to using terbutaline?

Be aware that serious side effects, including maternal heart problems and death, have been reported after prolonged use of terbutaline to manage preterm labor. There are serious situations where a healthcare professional may decide that the short-term use of injectable terbutaline in the hospital setting may benefit a pregnant woman.

How is terbutaline used as a bronchodilator?

Terbutaline is a beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. Terbutaline is indicated for prevention and reversal of bronchospasm in patients at least 12 years old, with asthma and reversible bronchospasm associated with bronchitis and emphysema. 16, 17

What does terbutaline do to the smooth muscle?

Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (beta2 receptors) than on the beta-receptors of the heart (beta1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation.

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