What is the function of IL-6?

What is the function of IL-6?

Immune system IL-6 is an important mediator of fever and of the acute phase response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.

Is IL-6 a transcription factor?

The transcriptional regulation of the IL-6 gene is complex and involves at least four different transcription factors, i.e., NF-κB, activator protein (AP)-1, CCAAT/enhancer binding protein (C/EBP), and cAMP response element (CRE)-binding protein (CREB) (1, 26).

Where is interleukin 6 produced?

Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase proteins.

How is the NF-IL6 gene related to IL-6?

Recombinant NF-IL6 activated the human IL-6 promoter in a sequence-specific manner. Southern blot analysis demonstrated the high-degree conservation of the NF-IL6 gene through evolution and the existence of several other related genes sharing the DNA-binding domain.

Is the expression of IL-6 restricted to certain tissues?

In contrast, the expression of CD126 is restricted to certain tissues. As IL-6 interacts with its receptor, it triggers the gp130 and IL-6R proteins to form a complex, thus activating the receptor.

How is intramuscular IL-6 expression regulated in macrophages?

It appears that unlike IL-6 signalling in macrophages, which is dependent upon activation of the NFκB signalling pathway, intramuscular IL-6 expression is regulated by a network of signalling cascades, including the Ca2+/NFAT and glycogen/p38 MAPK pathways.

How does IL-6 affect epigenetic modification in the brain?

Epigenetic modifications IL-6 has been shown to lead to several neurological diseases through its impact on epigenetic modification within the brain. IL-6 activates the Phosphoinositide 3-kinase (PI3K) pathway, and a downstream target of this pathway is the protein kinase B (PKB) (Hodge et al., 2007).