What is tetrazole used for?
A well-known tetrazole is dimethyl thiazolyl diphenyl tetrazolium bromide (MTT). This tetrazole is used in the MTT assay to quantify the respiratory activity of live cells culture, although it generally kills the cells in the process. Some tetrazoles can also be used in DNA assays.
Is tetrazole acidic or basic?
The acidic nature of tetrazole is similar to corresponding carboxylic acids, but there is a difference in annular tautomerism of ring tetrazoles to carboxylic acids. The acidic nature of tetrazole is mainly affected by substitution compound nature at C-5 position.
Which drug has tetrazole nucleus?
Some tetrazole-containing drugs such as losartan, valsartan, irbesartan and candesartan have already been used for the treatment of hypertension in clinical practice, demonstrating the potential of tetrazole derivatives as putative antihypertensive drugs .
Are tetrazoles aromatic?
Generally, dilute 1 H -tetrazole in acetonitrile is used for DNA synthesis in biochemistry. The presence of free N-H causes the acidic nature of tetrazoles and forms both aliphatic and aromatic heterocyclic compounds.
When does a load of tetrazole explode?
Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
What is the melting point of 1H tetrazole?
1-H-TETRAZOLE is stable at normal temperature and pressure but decomposes rapidly and explosively if heated above its melting point of 155-157° C (Chem. Rev 1947, 41, 5). Presents an extreme risk of explosion by shock, friction, fire or other sources of ignition. Reacts violently with strong oxidizers.
How is tetrazole used as a combustive material?
Other tetrazoles are used for their explosive or combustive properties, such as tetrazole itself and 5-aminotetrazole, which are sometimes used as a component of gas generators in automobile airbags. Tetrazole based energetic materials produce high-temperature, non-toxic reaction products such as water and nitrogen gas,…
How is 1h tetrazole used in DNA synthesis?
Tetrazole solution, for DNA synthesis, filtered through a 1 mum filter, ~0.45 M in acetonitrile 1H-tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition it emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire.