How does diabetes cause hyperlipidemia?
The central, abdominal distribution of adipose tissue in IDDM is associated with insulin resistance, hypertension, and the above lipoprotein abnormalities. Improvement in glucose control, in the absence of weight gain, leads to lower triglyceride and higher HDL cholesterol levels.
What is the pathophysiology of hyperlipidemia?
The pathophysiology of primary hyperlipidemia involve the idiopathic hyperchylomicronemia in which defect in lipid metabolism leads to hypertriglyceridemia and hyperchylomicronemia caused by a defect in lipoprotein lipase activity or the absence of the surface apoprotein CII31.
What is diabetic hyperlipidemia?
Diabetic hyperlipidemia is, in fact, having high cholesterol when you have diabetes. The parts of the word hyperlipidemia break into: hyper: high. lipid: scientific term referring to fat, cholesterol, and fat-like substances in the body. emia: in the blood.
Does diabetes 1 cause hyperlipidemia?
Poorly controlled type 1 diabetes and type 2 diabetes are associated with increased plasma levels of VLDL. Two factors may increase VLDL production in the liver: the return of more fatty acids due to increased actions of hormone-sensitive lipase (HSL) in adipose tissue and insulin actions directly on apoB synthesis.
What is the dyslipidemia of type 2 diabetes?
The dyslipidemia of type 2 diabetes is characterized by high triglyceride levels and decreased high-density lipoprotein (HDL) cholesterol, changes observed many years before the onset of clinically relevant hyperglycemia [, ].
What causes hyperlipidemia in non insulin-dependent diabetics?
The non-insulin-dependent diabetic (NIDDM) patient with mild fasting hyperglycemia commonly has mild hypertriglyceridemia due to overproduction of TG-rich lipoproteins in the liver, associated with decreased hi … Pathophysiology of hyperlipidemia in diabetes mellitus J Cardiovasc Pharmacol. 1990;16 Suppl 9:S1-7. Authors
What does hyperlipidemia stand for in medical category?
The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. Hyperlipidemia represents a subset of dyslipidemia and a superset of hypercholesterolemia.
What is the pathophysiology of diabetes mellitus ( IDDM )?
The more hyperglycemic untreated NIDDM and insulin-dependent diabetic (IDDM) patient have mild to moderate hypertriglyceridemia due to decreased adipose tissue and muscle lipoprotein lipase, (LPL) activity. These patients also have decreased HDL cholesterol levels associated with defective LPL catabolism of TG-rich lipoproteins.