Can Lyme cause a false positive mono test?
False positive serologies for Lyme disease have been previously reported in patients with acute infectious mononucleosis.
Can mono be mistaken for Lyme?
Lyme disease and infectious mononucleosis are common illnesses that share similar clinical presentations that are predominantly composed of non-specific symptoms including fatigue, fever, myalgia, arthritis, headaches, neck soreness, and lymphadenopathy. Both are common childhood illnesses in Lyme endemic regions.
What causes false positive IgM Lyme?
Infection with other diseases, including some tickborne diseases, or some viral, bacterial, or autoimmune diseases, can result in false positive test results. Some tests give results for two types of antibody, IgM and IgG. Positive IgM results should be disregarded if the patient has been ill for more than 30 days.
How common is a false positive Lyme test?
While these labs strive for high sensitivity they do not outperform reference labs in finding Lyme disease.  Moreover, specificity as low as 43% is reported, indicating that 57% of results coming from such labs are false positives.
Can a false positive for Lyme disease be mono?
False positive serologies for Lyme disease have been previously reported in patients with acute infectious mononucleosis. However, a recent paper describes two cases in which Lyme disease was misdiagnosed as mono based on false positive serologies for the Epstein-Barr virus (EBV).
What causes a false positive on a monospot test?
False positive causes for Monospot tests include: Pre-analytical laboratory problem (the most common cause, usually because of the problems noted above) Infectious Cytomegalovirus. Hepatitis. Influenza.
How many false negatives are there on Lyme disease tests?
With this test the proportion of errors due to false negatives is 12%, with an overall error rate of 1%. However, when specificity is also low, as for the alternative lab, [ 6] positive predictive value is markedly lower (approximately 1%).
When to use Western blot test for Lyme disease?
The Centers for Disease Control and Prevention recommend a two-step process for serologic testing: [ 3,4] when a positive or equivocal positive using a highly sensitive enzyme immunoassay is found, it is followed by a Western blot test, which is highly specific.