What is miR 27a?
PDBe. miR-27 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-27 precursor is the microRNA mir-27.
What is HSA miR 27b?
MicroRNA 27b microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.
How is HSA-mir-27a-3p in CSF related to dementia?
Results: The level of hsa-miR-27a-3p in CSF is reduced in patients with dementia due to AD in 2 different cohorts of subjects (cohort 1: p = 0.008; cohort 2: p = 0.015; 2-tailed unpaired Welch t test). Moreover, low levels of hsa-miR-27a-3p were accompanied by high CSF tau levels and low CSF β-amyloid levels.
How is miR-27a used to treat breast cancer?
MiR-27a sensitizes luminal A breast cancer cells to SERM treatments based on a positive feedback loop with ERalpha. Using direct sequencing approach for miR-23a/24-2/27a genes cluster, heterozygous (A/G allele) as well as homozygous (G/G allele) variants were detected in MIR27A in breast cancer patients.
What is the gene ID for mir27a microRNA?
MIR27A microRNA 27a [ (human)] Gene ID: 407018, updated on 25-Dec-2016. microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.
What is the role of mirnas-27a in cervical cancer?
INPP1 up-regulation by miR-27a contributes to the growth, migration and invasion of human cervical cancer. The expression levels of miRNAs- 27a and 23a in the peripheral blood mononuclear cells (PBMCs) and their correlation with FOXO1 and some inflammatory and anti-inflammatory cytokines in the patients with coronary artery disease (CAD).