What is H37Ra?

What is H37Ra?

The attenuated Mycobacterium tuberculosis strain H37Ra is one of the most commonly used controls for M. tuberculosis identification in the clinical laboratory and is a source of false-positive results for M. tuberculosis as a consequence of cross-contamination.

Why the Mycobacterium tuberculosis is acid resistant?

M. tuberculosis resists acidification with the help of the Rv3671c-encoded membrane-bound serine protease, the putative magnesium transporter MgtC, and the pore-forming M. tuberculosis outer membrane protein (OmpATb). The exact mechanisms by which these proteins confer acid resistance remain to be identified.

What toxins can Mycobacterium tuberculosis produce?

Upon host infection, Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) into the cytosol of infected macrophages, leading to host cell death by necroptosis. TNT hydrolyzes NAD+ in the absence of any exogenous cofactor, thus classifying it as a β-NAD+ glycohydrolase.

What’s the difference between H37Rv and H37Ra?

Some differences between the two strain have been noted. Although both H37Rv and H37Ra are able to infect macrophages equally, only H37Rv and not H37Ra was able to grow intracellularly as well as cause significant mitochondrial damage leading to necrosis.

Which is part of Mycobacterium tuberculosis is FASTA?

This proteome is part of the Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) pan proteome (fasta) Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis.

Why is Mycobacterium tuberculosis not a virulent organism?

Since the H37Ra strain does not revert to a virulent phenotype on passaging through animals, it is likely that the former has acquired multiple point mutations or small deletions/rearrangements in genes crucial for virulence. Some differences between the two strain have been noted.

What kind of biosafety is needed for tuberculosis?

Selecting the appropriate methods of biosafety protection for different pathogenic TB strains. Tuberculosis (TB) is a chronic infectious respiratory disease caused by Mycobacterium tuberculosis (MTB), which seriously endangers human health.