What does HLA DQ stand for?
HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. It is an αβ heterodimer of type MHC class II. The α and β chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.
What is HLA DQ test?
The HLA DQ Association test detects celiac disease-associated alleles that predispose to the disorder but is not diagnostic of celiac disease. More than 95% of celiac disease patients are positive for DQ2, half DQ2, or DQ8, but many individuals with these genetic results do not develop celiac disease.
What does HLA DQ2 positive mean?
If the test results are positive for HLA DQ2 or DQ8, your child is at risk of developing celiac disease. It doesn’t mean they will definitely have celiac disease and the chance of developing celiac disease is still low.
How common is HLA DQ8?
HLA DQ2/DQ8 was present in 98,4% of celiac patients; 89,6% relatives of celiac family and in 55,4% of people from the general population without family celiac.
How many copies of the HLA DQ gene do you have?
Everyone has HLA-DQ genes. In fact, everyone inherits two copies of HLA-DQ genes — one from their mother and one from their father. There are many different types of HLA-DQ genes, including HLA-DQ2, HLA-DQ8, HLA-DQ7, HLA-DQ9 and HLA-DQ1.
How is HLA-DQ used in the diagnosis of celiac disease?
HLA-DQ typing in the diagnosis of celiac disease HLA-DQ2 and -DQ8 determination is useful in exclusion, probably lifelong, of celiac disease in individuals with an equivocal small bowel histological finding. The low specificity of this test must, however, be borne in mind.
What are two autoimmune diseases associated with HLA-DQ?
Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants.
What is the sensitivity of HLA-DQ2 PCR?
Alleles tested: HLA-DQ2 (encoded by HLA-DQA1*05 and HLA-DQB1*02) and HLA-DQ8 (encoded by HLA-DQB1*03:02). Clinical Sensitivity and Specificity: Approximately 100 percent and 3 percent, respectively. Methodology: PCR with melting curve analysis. Analytical Sensitivity and Specificity: 99 percent.