Do B cells have CD20?

Do B cells have CD20?

CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.

What is CD20 a marker for?

A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 antigen on blood cells may help to diagnose cancer or plan cancer treatment. CD20 antigen is a type of tumor marker.

What does positive for CD20 mean?

CD20 positive T cell lymphoma is a rare condition that is characterized by the coexpression of CD20 and T cell markers, such as, CD3, CD5, or UCHL-11. Positivity for CD20 in any type of T cell lymphoma represents an aberrant immunophenotype, despite the presence of various indicators of T cell lymphoma.

What is a normal CD20 count?

Reference ranges for CD10, CD19, and CD20 were found to be 1–3 (median 1%), 6–23 (median 14%), and 6–23 (median 14%), respectively (Table 2). The distribution of these B-cell subsets’ reference ranges based on gender is shown in Table 3.

What is the role of CD20 in immunology?

CD20 is much used as a target for therapeutic monoclonal antibodies in the treatment of B cell malignancies and autoimmune disease. Its exact role in B cell function is not clear although it plays a role in Ca 2+ transport across the plasma membrane.

What is CD20 therapy?

CD20 is the target for Rituxan, the anti-CD20 molecular targeted therapy for CD20 positive lymphomas. This is a common theranostic use for lymphoma patients, as well as for patients with rheumatoid arthritis.

What does CD20 positive mean?

CD20 positive t cell lymphoma represents a small fraction of t cell lymphomas. The pathogenesis of CD20+ T cell lymphoma is not known. CD20 is a transmembrane protein that was first identified as a B cell marker in 1980. CD20 appears early in B cell development and remains present through the Plasma Cell stage of development.

What are symptoms of B cell lymphoma?

Symptoms vary according to the type of B-cell lymphoma and how advanced it is. These are some of the main symptoms: swollen lymph nodes in your neck, armpits, or groin. abdominal pain or swelling. chest pain. coughing. breathing difficulties. fever and night sweats.