What is aldol reaction with example?

What is aldol reaction with example?

‘Aldol’ is an abbreviation of aldehyde and alcohol. When the enolate of an aldehyde or a ketone reacts at the α-carbon with the carbonyl of another molecule under basic or acidic conditions to obtain β-hydroxy aldehyde or ketone, this reaction is called Aldol Reaction.

What are the four steps in the aldol reaction?

Step 1: The hydroxide ion deprotanates the aldehyde reversibly. Step 2: Enolate ion 1 adds to the unreacted aldehyde. Step 3: Alkoxide ion 2 is protonated by water. Step 4: Aldol 3 is an enolizable aldehyde.

What is aldol reaction explain?

An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone (an aldol reaction), followed by dehydration to give a conjugated enone.

What is the product of aldol condensation reaction?

The product formed in aldol condensation is beta hydroxy aldehyde or beta hydroxy ketone.

Why are aldol reactions important?

Aldol condensations are important in organic synthesis, because they provide a good way to form carbon–carbon bonds. For example, the Robinson annulation reaction sequence features an aldol condensation; the Wieland–Miescher ketone product is an important starting material for many organic syntheses.

Why aldol condensation is called condensation reaction?

The aldol condensation is a reaction that is named based on the type of product formed when two aldehydes (or ketones), in the presence of dilute base, yields a molecule having both alcohol and aldehyde functional groups.

What is the mechanism of an aldol addition?

Mechanism of the Aldol Addition Under conditions of kinetic control, the mixed Aldol Addition can be used to prepare adducts that are otherwise difficult to obtain selectively. This process begins with the irreversible generation of the kinetic enolate, e.g. by employing a sterically hindered lithium amide base such as LDA (lithium diisopropylamide).

What is a crossed aldol reaction?

In simple words, Crossed aldol reaction is the reaction between two different aldehydes, or 2 different ketones, or between an aldehyde and a ketone. For aldol reaction, alpha hydrogen is a necessary condition, but there are exceptions, which makes Crossed aldol, an important topic for exams.