How does cisplatin work with radiation?

How does cisplatin work with radiation?

A clear synergistic interaction between cisplatin and ionizing radiation (IR) is observed in cells proficient in non-homologous end joining (NHEJ) catalyzed repair of DNA double-strand breaks (DSB). In contrast, no interaction between cisplatin and IR is observed in NHEJ deficient cells.

What is Gy oncology?

Standard dose Gray (Gy) is the unit used to measure the total amount of radiation that the patient is exposed to. This can also be recorded as centigray (cGy), which is 0.01 of a single Gy unit. Adjuvant therapy doses typically range from 45 to 60 Gy for the treatment of breast, head, and neck cancers.

How does cisplatin kill cells?

Cisplatin is part of a group of medications called platinum analogues. It also belongs to a larger group of chemotherapy drugs known as alkylating agents. Cisplatin kills cells (including cancer cells and normal cells) by causing abnormal linkages in DNA, the genetic material of cells. This is known as cross-linking.

What is a side effect of chemotherapy and radiotherapy?

Other side effects that can occur later include: weakening of the bones in the treated area, which can lead to rib and collarbone fractures damage to the nerves in the arm on the treated side, which may cause tingling, numbness, pain, weakness and possibly some loss of movement developing another type of cancer in the future

Which is worse radiation or chemotherapy?

Nevertheless, chemotherapy comes with more severe side effects than radiation because all of the cells in the body may be affected by the drug being used; radiation therapy targets only specific areas of the body affected by cancerous cell growth. Common side effects of chemotherapy include nausea and hair loss,…

What is the nadir for cisplatin?

Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. These are less common Cisplatin side effects (occurring in 10-29%) for patients receiving Cisplatin: