What is Martin Rodbell known for?

What is Martin Rodbell known for?

G protein
Signal transduction
Martin Rodbell/Known for

How were G-proteins discovered?

G proteins were discovered when Alfred G. Gilman and Martin Rodbell investigated stimulation of cells by adrenaline. They found that when adrenaline binds to a receptor, the receptor does not stimulate enzymes (inside the cell) directly. Instead, the receptor stimulates a G protein, which then stimulates an enzyme.

Who discovered transduction?

Martin Rodbell
Martin Rodbell and his coworkers at the National Institutes of Health in Bethesda, USA, demonstrated, in a set of pioneering experiments conducted in the late 1960’s and early 1970’s, that the signal transduction through the cell membrane involves a cooperative action of three different functional entities (Fig. 1).

Who discovered G-proteins?

Discovery of G-proteins and the role of these proteins in signal transduction in cells. Martin Rodbell and Alfred G. Gilman were awarded the Nobel Prize in Physiology or Medicine in 1994 for their discovery of G-proteins, which are vital for passing on signals to the inside of cells from the outside.

What did Martin Rodbell do in the lab?

In December 1969 and early January 1970, Rodbell was working with a laboratory team that studied the effect of the hormone glucagon on a rat liver membrane receptor—the cellular discriminator that receives outside signals.

Why was Martin Rodbell awarded the Nobel Prize?

He shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman for “their discovery of G-proteins and the role of these proteins in signal transduction in cells.” Rodbell was born in Baltimore, Maryland, the son of Shirley (née Abrams) and Milton Rodbell, a grocer. His family was Jewish.

What did Martin Rodbell discover about the G protein?

This GTP, he found, stimulated the activity in the guanine nucleotide protein (later called the G-protein), which, in turn, produced profound metabolic effects in the cell. This activation of the G-protein, Rodbell postulated, was the ” second messenger ” process that Earl W. Sutherland had theorized.

How did Martin Rodbell die cause of death?

He died in Chapel Hill of multiple organ failure after an extended illness. Reflecting the increasingly common analogies between computer science and biology in the 1960s, Rodbell believed that the fundamental information processing systems of both computers and biological organisms were similar.